Vitamin B3 (Niacin)

vitamin

A water-soluble vitamin that supports energy metabolism, DNA repair, and skin health.

Definition

A water-soluble vitamin that supports energy metabolism, DNA repair, and skin health. DV is 16mg NE. High-dose niacin can raise HDL cholesterol. Found in meat, fish, whole grains, and peanuts.

๋น„ํƒ€๋ฏผ B3(๋‚˜์ด์•„์‹ , Niacin)์ด๋ž€?

๋‚˜์ด์•„์‹ (Niacin)์€ ๋ฐ€์ ‘ํ•˜๊ฒŒ ๊ด€๋ จ๋œ ๋‘ ํ™”ํ•ฉ๋ฌผ์ธ ๋‹ˆ์ฝ”ํ‹ด์‚ฐ(nicotinic acid)๊ณผ ๋‹ˆ์ฝ”ํ‹ด์•„๋งˆ์ด๋“œ(๋‚˜์ด์•„์‹ ์•„๋งˆ์ด๋“œ, niacinamide)๋ฅผ ํฌํ•จํ•˜๋Š” ์ˆ˜์šฉ์„ฑ B ๋น„ํƒ€๋ฏผ์ž…๋‹ˆ๋‹ค. ๋‘ ํ™”ํ•ฉ๋ฌผ ๋ชจ๋‘ ์ฒด๋‚ด์—์„œ ์ˆ˜๋ฐฑ ๊ฐ€์ง€ ํšจ์†Œ ๋ฐ˜์‘์— ํ•„์ˆ˜์ ์ธ ์กฐํšจ์†Œ์ธ ๋‹ˆ์ฝ”ํ‹ด์•„๋งˆ์ด๋“œ ์•„๋ฐ๋‹Œ ๋‹ค์ด๋‰ดํด๋ ˆ์˜คํƒ€์ด๋“œ(NAD)์™€ ๊ทธ ์ธ์‚ฐํ™” ํ˜•ํƒœ(NADP)๋กœ ์ „ํ™˜๋ฉ๋‹ˆ๋‹ค. ์ฒด๋‚ด์—์„œ ํ•„์ˆ˜ ์•„๋ฏธ๋…ธ์‚ฐ ํŠธ๋ฆฝํ† ํŒ์œผ๋กœ๋ถ€ํ„ฐ๋„ ์†Œ๋Ÿ‰์˜ ๋‚˜์ด์•„์‹ ์„ ํ•ฉ์„ฑํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค(ํŠธ๋ฆฝํ† ํŒ ์•ฝ 60 mg์ด ๋‚˜์ด์•„์‹  ๋‹น๋Ÿ‰ 1 mg์„ ์ƒ์„ฑ).

RDA๋Š” ๋‚จ์„ฑ ํ•˜๋ฃจ 16 mg NE, ์—ฌ์„ฑ ํ•˜๋ฃจ 14 mg NE์ž…๋‹ˆ๋‹ค. ๋ณด์ถฉ์ œ ํ˜•ํƒœ์˜ ๋‹ˆ์ฝ”ํ‹ด์‚ฐ์— ๋Œ€ํ•œ ํ—ˆ์šฉ ์ƒํ•œ ์„ญ์ทจ๋Ÿ‰(UL)์€ ํ™์กฐ ๋ฐ˜์‘์œผ๋กœ ์ธํ•ด ํ•˜๋ฃจ 35 mg์ž…๋‹ˆ๋‹ค.

์ฃผ์š” ๊ธฐ๋Šฅ

  • ์—๋„ˆ์ง€ ๋Œ€์‚ฌ: NAD์™€ NADP๋Š” ํ•ด๋‹น ๊ณผ์ •, TCA ํšŒ๋กœ, ์ง€๋ฐฉ์‚ฐ ํ•ฉ์„ฑ์„ ํฌํ•จํ•œ 400๊ฐ€์ง€ ์ด์ƒ์˜ ์‚ฐํ™”-ํ™˜์› ๋ฐ˜์‘์— ์ฐธ์—ฌํ•ฉ๋‹ˆ๋‹ค.
  • DNA ๋ณต๊ตฌ: NAD๋ฅผ ๊ธฐ์งˆ๋กœ ์‚ฌ์šฉํ•˜๋Š” PARP(ํด๋ฆฌ-ADP-๋ฆฌ๋ณด์Šค ์ค‘ํ•ฉํšจ์†Œ)๋Š” DNA ์‚ฌ์Šฌ ์ ˆ๋‹จ ๋ณต๊ตฌ์— ํ•„์ˆ˜์ ์ž…๋‹ˆ๋‹ค.
  • ์„ธํฌ ์‹ ํ˜ธ ์ „๋‹ฌ: NAD๋Š” ๋Œ€์‚ฌ ์กฐ์ ˆ ๋ฐ ๋…ธํ™” ์—ฐ๊ตฌ์™€ ์—ฐ๊ด€๋œ ํƒˆ์•„์„ธํ‹ธํ™” ํšจ์†Œ ์‹œ๋ฅดํˆฌ์ธ(sirtuin)์˜ ๊ธฐ์งˆ๋กœ ๊ธฐ๋Šฅํ•ฉ๋‹ˆ๋‹ค.

๊ฒฐํ•, ๋…์„ฑ ๋ฐ ์‹ํ’ˆ ๊ณต๊ธ‰์›

๋‚˜์ด์•„์‹  ๊ฒฐํ•์€ "4D"๋กœ ํŠน์ง•์ง€์–ด์ง€๋Š” ํŽ ๋ผ๊ทธ๋ผ(Pellagra)๋ฅผ ์œ ๋ฐœํ•ฉ๋‹ˆ๋‹ค: ํ”ผ๋ถ€์—ผ(dermatitis)(๊ด‘๊ณผ๋ฏผ์„ฑ ํ”ผ๋ถ€ ๋ฐœ์ง„), ์„ค์‚ฌ(diarrhea), ์น˜๋งค(dementia), ์น˜๋ฃŒํ•˜์ง€ ์•Š์œผ๋ฉด ์‚ฌ๋ง(death). ๊ณ ์šฉ๋Ÿ‰ ๋‹ˆ์ฝ”ํ‹ด์‚ฐ(ํ•˜๋ฃจ 1โ€“3 g)์€ HDL ์ฝœ๋ ˆ์Šคํ…Œ๋กค์„ ๋†’์ด๊ณ  ์ค‘์„ฑ์ง€๋ฐฉ์„ ๋‚ฎ์ถ”๊ธฐ ์œ„ํ•œ ์ž„์ƒ ์น˜๋ฃŒ์— ์‚ฌ์šฉ๋˜์ง€๋งŒ, ์˜๋ฃŒ์  ๊ฐ๋…์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.

๋‚˜์ด์•„์‹ ์ด ํ’๋ถ€ํ•œ ์‹ํ’ˆ์œผ๋กœ๋Š” ๋‹ญ๊ฐ€์Šด์‚ด, ์ฐธ์น˜, ์—ฐ์–ด, ์‡ ๊ณ ๊ธฐ, ๋•…์ฝฉ, ๊ฐ•ํ™” ์‹œ๋ฆฌ์–ผ์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์˜ฅ์ˆ˜์ˆ˜ ๊ธฐ๋ฐ˜ ์‹์ด๋Š” ์•Œ์นผ๋ฆฌ ์ฒ˜๋ฆฌ(๋‹ˆ์Šคํƒ€๋งํ™”, nixtamalization)๋ฅผ ํ•˜์ง€ ์•Š์œผ๋ฉด ๊ฒฐํ•ฉ๋œ ๋‚˜์ด์•„์‹ ์ด ๋ฐฉ์ถœ๋˜์ง€ ์•Š์•„ ํŽ ๋ผ๊ทธ๋ผ ์œ„ํ—˜์ด ์žˆ์Šต๋‹ˆ๋‹ค.