Tolerable Upper Intake Level (UL)

general

The maximum daily intake of a nutrient unlikely to cause adverse health effects in most people.

Definition

The maximum daily intake of a nutrient unlikely to cause adverse health effects in most people. Exceeding the UL increases risk of toxicity. Established for most vitamins and minerals.

์ƒํ•œ ์„ญ์ทจ๋Ÿ‰(Tolerable Upper Intake Level)์ด๋ž€ ๋ฌด์—‡์ธ๊ฐ€์š”?

์ƒํ•œ ์„ญ์ทจ๋Ÿ‰(Tolerable Upper Intake Level, UL)์€ ์ผ๋ฐ˜ ์ธ๊ตฌ์˜ ๊ฑฐ์˜ ๋ชจ๋“  ๊ฐœ์ธ์—๊ฒŒ ๊ฑด๊ฐ•์— ๋ถ€์ •์ ์ธ ์˜ํ–ฅ์„ ์ค„ ์œ„ํ—˜์ด ์—†์„ ๊ฒƒ์œผ๋กœ ์˜ˆ์ƒ๋˜๋Š” ์ตœ๋Œ€ ํ‰๊ท  ์ผ์ผ ์˜์–‘์†Œ ์„ญ์ทจ๋Ÿ‰ ์ˆ˜์ค€์ž…๋‹ˆ๋‹ค. ๋ฏธ๊ตญ ๊ตญ๋ฆฝ๊ณผํ•™๊ณตํ•™์˜ํ•™์›(NASEM)์ด ์‹์ด ์ฐธ๊ณ  ์„ญ์ทจ๋Ÿ‰(DRI) ์ฒด๊ณ„์˜ ์ผ๋ถ€๋กœ ์ˆ˜๋ฆฝํ•œ UL์€ ๊ถŒ์žฅ ์„ญ์ทจ ๋ชฉํ‘œ๊ฐ€ ์•„๋‹Œ ์•ˆ์ „ ์ƒํ•œ์„ ์„ ๋‚˜ํƒ€๋ƒ…๋‹ˆ๋‹ค.

์„ญ์ทจ๋Ÿ‰์ด UL์„ ์ดˆ๊ณผํ•˜๋ฉด ๋ถ€์ •์  ์˜ํ–ฅ์˜ ์ž ์žฌ์  ์œ„ํ—˜์ด ์ฆ๊ฐ€ํ•ฉ๋‹ˆ๋‹ค. UL์€ ์‹ํ’ˆ, ์Œ๋ฃŒ, ๋ณด์ถฉ์ œ๋ฅผ ํ•ฉ์‚ฐํ•œ ๋ชจ๋“  ๊ธ‰์›์œผ๋กœ๋ถ€ํ„ฐ์˜ ์ด ์„ญ์ทจ๋Ÿ‰์— ์ ์šฉ๋˜์ง€๋งŒ, ๋Œ€๋ถ€๋ถ„์˜ ์˜์–‘์†Œ์—์„œ ์‹์ด ์„ญ์ทจ๋งŒ์œผ๋กœ๋Š” UL์— ๊ฑฐ์˜ ๊ทผ์ ‘ํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ๋ณด์ถฉ์ œ๊ฐ€ ๊ฐœ์ธ์ด ์•ˆ์ „ ์ƒํ•œ์„ ์„ ์ดˆ๊ณผํ•  ์ˆ˜ ์žˆ๋Š” ์ฃผ์š” ๊ฒฝ๋กœ์ž…๋‹ˆ๋‹ค.

์„ ํƒ ์˜์–‘์†Œ์˜ UL ๊ฐ’

  • ๋น„ํƒ€๋ฏผ A(์˜ˆ์„ฑํ˜•): 3,000 mcg RAE/์ผ. ๊ณผ์ž‰ ์„ญ์ทจ๋Š” ๊ฐ„ ์†์ƒ, ๊ณจ ์†์‹ค, ์ตœ๊ธฐํ˜•์„ฑ(์„ ์ฒœ์„ฑ ๊ธฐํ˜•)์„ ์œ ๋ฐœํ•ฉ๋‹ˆ๋‹ค.
  • ๋น„ํƒ€๋ฏผ D: 100 mcg (4,000 IU)/์ผ. ๊ณผ๋„ํ•œ ์„ญ์ทจ๋Š” ๊ณ ์นผ์Š˜ํ˜ˆ์ฆ(hypercalcemia), ์‹ ์žฅ ๊ฒฐ์„, ์—ฐ์กฐ์ง ์„ํšŒํ™”๋ฅผ ์œ ๋ฐœํ•ฉ๋‹ˆ๋‹ค.
  • ๋‚˜์ด์•„์‹ (๋‹ˆ์ฝ”ํ‹ด์‚ฐ ํ˜•ํƒœ): 35 mg/์ผ. ๊ณ ์šฉ๋Ÿ‰์€ ํ™์กฐ(flushing)๋ฅผ ์œ ๋ฐœํ•˜๊ณ , ์ง€์†์ ์œผ๋กœ ์„ญ์ทจ ์‹œ ๊ฐ„ ๋…์„ฑ์ด ๋‚˜ํƒ€๋‚ฉ๋‹ˆ๋‹ค.
  • ์—ฝ์‚ฐ(๋ณด์ถฉ์ œ ํ˜•ํƒœ): 1,000 mcg/์ผ. ๊ณผ์ž‰ ์„ญ์ทจ๋Š” ๋น„ํƒ€๋ฏผ B12 ๊ฒฐํ•์„ ๊ฐ€๋ฆด ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
  • ์นผ์Š˜: 2,500 mg/์ผ(19~50์„ธ), 2,000 mg/์ผ(51์„ธ ์ด์ƒ). ๊ณผ์ž‰ ์„ญ์ทจ๋Š” ์‹ ์žฅ ๊ฒฐ์„๊ณผ ๊ด€๋ จ์ด ์žˆ์œผ๋ฉฐ ์ฒ  ๋ฐ ์•„์—ฐ ํก์ˆ˜๋ฅผ ์ €ํ•ดํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
  • ์ฒ : 45 mg/์ผ. ๊ณผ์ž‰ ์„ญ์ทจ๋Š” ์œ„์žฅ๊ด€ ๋ถˆํŽธ์„ ์œ ๋ฐœํ•˜๊ณ , ์œ ์ „์„ฑ ํ˜ˆ์ƒ‰์†Œ์ฆ(hereditary hemochromatosis)์—์„œ๋Š” ์žฅ๊ธฐ ์†์ƒ์„ ์œ ๋ฐœํ•ฉ๋‹ˆ๋‹ค.
  • ์•„์—ฐ: 40 mg/์ผ. ๋งŒ์„ฑ์ ์ธ ๊ณผ์ž‰ ์„ญ์ทจ๋Š” ๊ตฌ๋ฆฌ ํก์ˆ˜๋ฅผ ๋ฐฉํ•ดํ•ฉ๋‹ˆ๋‹ค.

๋ชจ๋“  ์˜์–‘์†Œ์— UL์ด ์ •์˜๋˜์–ด ์žˆ์ง€๋Š” ์•Š์Šต๋‹ˆ๋‹ค

๋ถ€์ž‘์šฉ ์ˆ˜์ค€์„ ํŒŒ์•…ํ•˜๊ธฐ์— ์ถฉ๋ถ„ํ•œ ๋ฐ์ดํ„ฐ๊ฐ€ ์—†๋Š” ๊ฒฝ์šฐ UL์ด ์„ค์ •๋˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ์ด๊ฒƒ์ด ๊ณ ์šฉ๋Ÿ‰ ์„ญ์ทจ๊ฐ€ ์•ˆ์ „ํ•˜๋‹ค๋Š” ์˜๋ฏธ๋Š” ์•„๋‹™๋‹ˆ๋‹ค โ€” ๋‹จ์ง€ ๋ฐ์ดํ„ฐ ๊ณต๋ฐฑ์„ ๋ฐ˜์˜ํ•  ๋ฟ์ž…๋‹ˆ๋‹ค. UL์ด ์—†๋Š” ์˜์–‘์†Œ๋กœ๋Š” ๋น„ํƒ€๋ฏผ K, ํ‹ฐ์•„๋ฏผ, ๋ฆฌ๋ณดํ”Œ๋ผ๋นˆ, ๋น„ํƒ€๋ฏผ B12, ํŒํ† ํ…์‚ฐ, ๋น„์˜คํ‹ด์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋“ค์— ๋Œ€ํ•ด์„œ๋Š” ๋ณด์ถฉ์ œ๋ฅผ ํ†ตํ•ด RDA๋ฅผ ํฌ๊ฒŒ ์ดˆ๊ณผํ•˜๋Š” ์–‘์„ ์„ญ์ทจํ•˜๋Š” ๊ฒƒ๋„ ์—ฌ์ „ํžˆ ์ฃผ์˜๋ฅผ ๊ธฐ์šธ์—ฌ ์ ‘๊ทผํ•ด์•ผ ํ•˜๋ฉฐ, ์ด์ƒ์ ์œผ๋กœ๋Š” ์˜๋ฃŒ ์ œ๊ณต์ž์™€ ์ƒ๋‹ดํ•˜๋Š” ๊ฒƒ์ด ์ข‹์Šต๋‹ˆ๋‹ค.